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In two placebo-managed human abuse prospective scientific tests, solitary oral doses of CONCERTA® were compared to single oral doses of quick-release methylphenidate (IR MPH) and placebo in subjects using a historical past of leisure stimulant use to evaluate relative abuse likely.

Methylphenidate may very well be behavior-forming, and this medicine is really a drug of abuse. Inform your health care provider When you have experienced issues with drug or alcohol abuse.

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Adverse gatherings during exposure have been attained primarily by standard inquiry and recorded by medical investigators working with their particular terminology.

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If advancement just isn't check here noticed following correct dosage adjustment above a one-month interval, the drug ought to be discontinued.

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Immediately after oral dosing of radiolabeled methylphenidate in individuals, about 90% on the radioactivity was recovered in urine. The leading urinary metabolite was PPAA, accounting for about eighty% of the dose.

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